January 5, 1986
Brian M. Susskind
Assistant Professor, Surgery
and Microbiology and Immunology Medical College
Box 629, MCV Station
Richmond, VA 23298
Enclosed please find January’s check for our contracted research.
Fortunately, we now have all other research grants paid off, including
Bowman Gray School of Medicine, yours remaining.
Hopefully I’ll be able to continue paying you — but please keep in mind that we
are in continuous court battle with [deleted] , and the problems do not seem to go
Reference your letter of 12/29/86 to Paul
Pybus: Your comments via effects on macrophages are certainly appropo. As I
recall, Roger Wyburn-Mason inserted metronidasole in one knee but not the
other, and the inflammation
was quenched (but it might have been clotrimasole) Whether one or the other, the
main findings with Pybus/Davis and Kwang Jeon is that
knee effusions containing metronidasole (systemically) had no living macrophages
and no growth in the laboratory, whereas those without
treatment by metronidasole had living macrophages and they grew (or similar organisms) grew
in the laboratory.
According to Pybus’ report when speaking to Smith of Bowman Gray, Clotrimasole did not
have the same effects.
So I was a little bewildered why the reference to Clotrimasole with respect to the “killing of macroph-
Perry A. Chapdelaine, Sr.